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Organic compounds in which a hydrogen atom or more has been replaced by a halogen atom in an alkane molecule (saturated hydrocarbon chain). Halogen atoms include bromine, chlorine, fluorine, and iodine. Compounds may be in closed ring configurations.
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Vilagletistat (ZED-1227) is a specific and orally active transglutaminase 2 (TG2) inhibitor, with an IC50 of 45 nM. It effectively blocks inflammation-induced TG2 expression and activity, making it suitable for research into celiac disease (CeD).
Specific and orally active TG2 inhibitor
IC50 of 45 nM against TG2
Blocks inflammation-induced TG2 expression and activity
Suitable for research of celiac disease (CeD)
Shows no cytotoxic activity in Huh7 and CaCo2 cells
Inhibits TG2 in small intestinal mucosa both in vitro and in vivo
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(-)-Alkannin is a naturally occurring naphthoquinone used in research as an apoptosis inducer that can arrest the cell cycle. It is supplied as a high-purity solid suitable for biochemical and cell-based studies, provided in small packaging for limited-scale experiments.
Apoptosis inducer and cell cycle arrest agent.
High purity suitable for analytical and biological assays.
Solid, brown to red appearance for easy handling.
Available in small package sizes (including 10 mg) for pilot studies.
Recommended storage conditions provided for powder and solutions.
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Dichloromethane has been tested as a solvent medium for dipyridine-chromium(VI) oxide. Solubility was reported to be 12.5g/100ml. Role of the quantity of TiO2 loading on activated carbon support on dichloromethane photodecomposition has been investigated.
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360A iodide (CAS 737763-37-0) is a 2 6-pyridine-dicarboxamide derivative that acts as a selective ligand for G-quadruplex DNA structures By stabilizing telomeric G-quadruplexes 360A inhibits telomerase activity and induces alterations in cell cycle progression notably causing S-phase accumulation in ATM-proficient EBV-lymphocytes Its mechanism of action involves promoting sister telomere fusions via DNA-PKcs-dependent non-homologous end joining (NHEJ) as well as triggering NHEJ and homologous recombination (HR) pathways at telomeres which disrupt mitotic progression 360A has been shown to preferentially bind telomeric G-quadruplex DNA over duplex DNA and to delay growth in HT1080 tumor cells This compound is valuable for investigating telomere biology DNA damage response and G-quadruplex-mediated genomic stability
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More